کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2782145 1153344 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The incidence of osteopenia and osteoporosis in women with hip osteoarthritis scheduled for cementless total joint replacement
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
The incidence of osteopenia and osteoporosis in women with hip osteoarthritis scheduled for cementless total joint replacement
چکیده انگلیسی

IntroductionThe co-existence of osteoporosis (OP) and osteoarthritis (OA) remains obscure. No systematic studies have been carried out to exclude the possibility that especially female osteoarthritic patients selected for cementless total hip arthroplasty (THA) suffer from primary or secondary OP.MethodsA subgroup of fifty-three female patients (average age, 64.7 years) with advanced primary hip OA scheduled for cementless THA were recruited for DXA and laboratory screening. Before surgery, bone mineral density (BMD) of the lumbar spine, the proximal femurs and the distal forearm were measured. The serum concentrations of calcium, 25-hydroxyvitamin D, parathyroid hormone and biochemical markers of bone resorption and formation were determined to exclude secondary OP.ResultsThe prevalence of OP (T score < − 2.5) and osteopenia (− 1.0 > T score > − 2.5) were 28% and 45%, respectively. Statistically, OP was related to patient's age, low BMI, postmenopausal status and not having estrogen replacement therapy. Five patients (9%) had laboratory findings of secondary OP. Two of them were found to have a parathyroid adenoma. The prevalence of vitamin D insufficiency [S-25(OH)D levels ≤ 50 nmol/l] was 36% (n = 19). As a sign of high bone turnover, the patients with reduced BMD values showed significantly increased serum levels of osteocalcin (p = 0.049), intact procollagen type I N propeptide (p = 0.040) and N-terminal crosslinking telopeptide of type I collagen (p = 0.046). The BMC of the femoral necks of the osteoarthritic hips were significantly higher (p < 0.001) and the BMC of the trochanter regions significantly lower (p = 0.005) compared to the contralateral hips.ConclusionAgainst a general belief, OA does not seem to protect a patient from generalized primary OP. The majority (74%) of the female hip OA patients were osteopenic or osteoporotic with signs of increased bone turnover. The observed prevalence of reduced BMD corresponds with the published data of age-matched population. An unexpectedly high number of patients required preoperative consultation with an endocrinologist. The altered distribution of BMD observed in the proximal femurs may explain the lower prevalence of fractures reported in the femoral necks of osteoarthritic hips.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 40, Issue 4, April 2007, Pages 1041–1047
نویسندگان
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