کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2782602 1153354 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strontium ranelate: A physiological approach for an improved bone quality
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Strontium ranelate: A physiological approach for an improved bone quality
چکیده انگلیسی

In vitro studies have suggested that strontium ranelate enhances osteoblastic cell replication leading to an increase in bone-forming activity. Simultaneously, strontium ranelate dose dependently decreases osteoclastic activity. In vivo studies indicate that strontium ranelate decreases bone resorption and maintains a high bone formation and prevents bone loss. This positive uncoupling between bone formation and bone resorption results in bone gain and improvement in bone geometry and microarchitecture in growing animals. In intact female rats, a 2-year period of exposure to strontium ranelate significantly increased bone mechanical properties of vertebrae and midshaft femur. All the determinants of bone strength were positively influenced by the treatment like bone mass, dimension, microarchitecture, and intrinsic bone tissue quality. The increment in bone mechanical properties was characterized by an increase in maximal load but also by a dramatic improvement in energy to failure, which was essentially due to an increment in plastic energy. Such modifications observed with strontium ranelate treatment are in good agreement with the improvement in intrinsic bone quality. These results strongly suggest that new bone formed following strontium ranelate treatment is able to withstand greater deformation before fracture. Furthermore, treatment with strontium ranelate prevents the deleterious effect of ovariectomy on bone strength. In this model, a 1-year period of exposure to strontium ranelate significantly prevents alteration of bone mechanical properties of vertebrae in association with a partial preservation of the trabecular microarchitecture: a dose-dependent effect on the bone volume/trabecular volume ratio and trabecular number and thickness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 38, Issue 2, Supplement 1, February 2006, Pages 15–18
نویسندگان
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