کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2786145 1568402 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic regulation of neural stem cell fate during corticogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Epigenetic regulation of neural stem cell fate during corticogenesis
چکیده انگلیسی

The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.


► Development of NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis.
► Epigenetic modifications contribute to the regulation of NSCs fate specification during corticogenesis.
► Transcriptional repression is the central mechanism in controlling fate specification of cortical projection neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 31, Issue 6, October 2013, Pages 424–433
نویسندگان
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