کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2791588 1154959 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ruling in or ruling out thyroid malignancy by molecular diagnostics of thyroid nodules
ترجمه فارسی عنوان
تشخیص مولکولی ندول های تیروئید در مواردی که بدخیمی تیرویید را کنترل یا حذف می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

Routine morphologic cytology is the basis for any kind of (integrated) molecular FNA diagnostics. The rule out (gene expression classifier) approach requires confirmation by independent studies, whereas the rule in approach (detection of BRAF, NRAS, HRAS, and KRAS and PAX8/PPARG- and RET/PTC rearrangements) has been investigated by several groups with overall reproducible results. Moreover, molecular screening for point mutations and rearrangements is feasible in routine air-dried FNA smears, offering several advantages over obtaining additional fresh FNA material. The current panel of somatic mutations (rule in approach) for indeterminate FNAs clarifies only a subgroup of indeterminate FNAs. Therefore, further markers are urgently needed that can reliably identify the malignant, but mutation negative and especially the many benign nodules, among the indeterminate FNAs. miRNA markers and the targeted next generation sequencing (NGS) technology do have the potential to identify those nodules that are mutation negative by current approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 28, Issue 4, August 2014, Pages 545–557
نویسندگان
, , ,