کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2791756 1154971 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
چکیده انگلیسی

The epidermis is a stratified squamous epithelium composed of proliferating basal and differentiated suprabasal keratinocytes. It serves as the body's major physical and chemical barrier against infection and harsh environmental insults, as well as preventing excess water loss from the body into the atmosphere. Calcium is a key regulator of the proliferation and differentiation in keratinocytes. Elevated extracellular Ca2+ concentration ([Ca2+]o) raises the levels of intracellular free calcium ([Ca2+]i), promotes cell–cell adhesion, and activates differentiation-related genes. Keratinocytes deficient in the calcium-sensing receptor fail to respond to [Ca2+]o stimulation and to differentiate, indicating a role for the calcium-sensing receptor in transducing the [Ca2+]o signal during differentiation. The concepts derived from in vitro gene knockdown experiments have been evaluated and confirmed in three mouse models in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 27, Issue 3, June 2013, Pages 415–427
نویسندگان
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