کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2791885 1154982 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SDH-related pheochromocytoma and paraganglioma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
SDH-related pheochromocytoma and paraganglioma
چکیده انگلیسی

Pheochromocytoma and paraganglioma are rare tumors of adrenals as well as the sympathetic and parasympathetic paraganglia. Clinical presentation of these tumors depends on localization, secretory profile and malignant potential. Four distinct syndromes – PGL1–4 – are related to mutations in the succinate dehydrogenase gene – mitochondrial complex involved in electron transfer and Krebs cycle. Here we describe etiology, genetics, as well as clinical aspects of SDH-related tumors. We also describe recent discoveries in HIF-related pathway of tumorigenesis and mutations in new SDH-related genes that have improved our understanding of this disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 24, Issue 3, June 2010, Pages 415–424
نویسندگان
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