کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2792981 1155102 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans
چکیده انگلیسی

SummarySerotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.

Graphical AbstractFigure optionsDownload high-quality image (126 K)Download as PowerPoint slideHighlights
► C. elegans counterparts of obesity genes mediate serotonergic feeding behavior
► Serotonin signaling causes inhibition of AMP-activated kinase
► Inhibition of AMP-activated kinase promotes glutamatergic release

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 1, 3 July 2012, Pages 113–121
نویسندگان
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