کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2793328 1155133 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
چکیده انگلیسی

SummaryAge-related disease, not aging per se, causes most morbidity in older humans. Here we report that skeletal muscle respiratory uncoupling due to UCP1 expression diminishes age-related disease in three mouse models. In a longevity study, median survival was increased in UCP mice (animals with skeletal muscle-specific UCP1 expression), and lymphoma was detected less frequently in UCP female mice. In apoE null mice, a vascular disease model, diet-induced atherosclerosis was decreased in UCP animals. In agouti yellow mice, a genetic obesity model, diabetes and hypertension were reversed by induction of UCP1 in skeletal muscle. Uncoupled mice had decreased adiposity, increased temperature and metabolic rate, elevated muscle SIRT and AMP kinase, and serum characterized by increased adiponectin and decreased IGF-1 and fibrinogen. Accelerating metabolism in skeletal muscle does not appear to impact aging but may delay age-related disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 6, Issue 6, 5 December 2007, Pages 497–505
نویسندگان
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