کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2793616 1155161 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Transcriptional Coactivator PGC-1β Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The Transcriptional Coactivator PGC-1β Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
چکیده انگلیسی

SummarySkeletal muscle must perform different kinds of work, and distinct fiber types have evolved to accommodate these. Previous work had shown that the transcriptional coactivator PGC-1α drives the formation of type I and IIA muscle fibers, which are “slow-twitch” and highly oxidative. We show here that transgenic expression of PGC-1β, a coactivator functionally similar to but distinct from PGC-1α, causes a marked induction of IIX fibers, which are oxidative but have “fast-twitch” biophysical properties. PGC-1β coactivates the MEF2 family of transcription factors to stimulate the type IIX myosin heavy chain (MHC) promoter. PGC-1β transgenic muscle fibers are rich in mitochondria and are highly oxidative, at least in part due to coactivation by PGC-1β of ERRα and PPARα. Consequently, these transgenic animals can run for longer and at higher work loads than wild-type animals. Together, these data indicate that PGC-1β drives the formation of highly oxidative fibers containing type IIX MHC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 5, Issue 1, January 2007, Pages 35–46
نویسندگان
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