کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796165 1568804 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Switching from atorvastatin to rosuvastatin lowers small, dense low-density lipoprotein cholesterol levels in Japanese hypercholesterolemic patients with type 2 diabetes mellitus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Switching from atorvastatin to rosuvastatin lowers small, dense low-density lipoprotein cholesterol levels in Japanese hypercholesterolemic patients with type 2 diabetes mellitus
چکیده انگلیسی


• Small dense LDL-cholesterol (sd LDL-C) levels without high LDL-C levels are involved in the development of arteriosclerosis due to lipid abnormalities in patients with type 2 diabetes mellitus.
• 129 subjects among a total of 230 outpatient subjects with T2DM who were currently receiving 10 mg atorvastatin once daily for ≥24 weeks were detected sd LDL-C using the LipoPhor AS® system.
• Switching from 10 mg atorvastatin to 5 mg rosuvastatin exhibited a statistically significant reduction from baseline of sd LDL-C levels.

AimsThis open-label, randomized, parallel-group comparative study compared the efficacy of rosuvastatin (5 mg/day) and atorvastatin (10 mg/day) for reduction of small dense low-density lipoprotein cholesterol (sd LDL-C) levels in Japanese patients with type 2 diabetes mellitus (T2DM).MethodsPatients with T2DM and hypercholesterolemia with detectable sd LDL-C after receiving 10 mg/day atorvastatin for ≥24 weeks were randomly assigned to receive rosuvastatin (5 mg/day; switched treatment) or atorvastatin (10 mg/day; continued treatment) for 12 weeks. The primary endpoints were changes in sd LDL-C levels and sd LDL-C/total LDL-C ratio evaluated using the LipoPhor AS® system.ResultsThere were no significant percent changes from baseline for LDL-C levels between the switched (n = 55) and the continued treatment group (n = 56). However, the former group exhibited a statistically significant reduction from baseline of sd LDL-C levels, sd LDL-C/total LDL-C ratio compared with the latter group (−3.8 mg/dL vs. −1.4 mg/dL, p = 0.014; −2.3% vs. −0.6%, p = 0.004, respectively). Multiple regression analysis among all subjects revealed that independent factors contributing to the reduction in sd LDL-C levels were a change in LDL-C (p = 0.003) and triglyceride (TG) levels (p = 0.006), treatment group (the switched group = 1, the continued group = 0; standard coefficient = −1.2, p = 0.034) and baseline glycated hemoglobin A1c (HbA1c) (p = 0.045), respectively.ConclusionSwitching from 10 mg atorvastatin to 5 mg rosuvastatin may be a useful therapeutic option to reduce sd LDL-C levels in Japanese hypercholesterolemic patients with T2DM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 111, January 2016, Pages 66–73
نویسندگان
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