کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796467 1155602 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 5-time point oral glucose tolerance test as a predictor of new-onset diabetes after kidney transplantation
ترجمه فارسی عنوان
آزمون 5 دقیقه تحمل گلوکز خوراکی به عنوان پیش بینی کننده ابتلا دیابت بعد از پیوند کلیه
کلمات کلیدی
محدوده تحت منحنی زمان غلظت گلوکز، تست تحمل گلوکز خوراکی پنج نقطه ای، پیوند کلیه، دیابت تازه شروع پس از پیوند، غلظت گلوکز پلاس پلاس پلاس /
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimsTo evaluate the predictive power of the 5-time point oral glucose tolerance test (OGTT) for new-onset diabetes after kidney transplantation (NODAT).MethodsWe performed a retrospective study of 145 patients without diabetes who received kidney transplantations at our hospital. The 5-time point OGTT was performed before transplantation. The area under a receiver-operating characteristic curve (aROC) was used for evaluating the predictive power of 5-time point OGTT values.ResultsSeventeen patients developed NODAT within 1 year after transplantation. All postload plasma glucose (PPG) levels were higher in patients who developed NODAT than in those who did not; fasting plasma glucose levels were not different. The aROC for the area under the glucose concentration-time curve was significantly greater than that for fasting plasma glucose. Univariate and multivariate analyses showed that each PPG level was an independent risk factor for NODAT. Furthermore, patients with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT) could be stratified with a 1-h plasma glucose (1h-PG) cut-off point of 8.4 mmol/L. The incidences of NODAT were 23.5%, 16.7%, 9.1%, and 0% for patients with IGT + 1h-PG ≥8.4 mmol/L,IGT + 1h-PG <8.4 mmol/L, NGT + 1h-PG ≥ 8.4 mmol/L, and NGT + 1h-PG < 8.4 mmol/L, respectively.ConclusionsThe area under the glucose concentration-time curve and each PPG concentration during the 5-time point OGTT are strong predictors of NODAT. A 1h-PG cut-off point of 8.4 mmol/L plus NGT/IGT can be used to identify patients at intermediate and high risk of developing NODAT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 103, Issue 2, February 2014, Pages 298–303
نویسندگان
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