کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796640 1155609 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: An observational study from the Swedish National Diabetes Register (NDR)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: An observational study from the Swedish National Diabetes Register (NDR)
چکیده انگلیسی

AimsAssessing the association between BMI and risk of coronary heart disease (CHD), cardiovascular disease (CVD) and mortality in patients with type 2 diabetes, also with regard to higher or lower levels of the ratio triglycerides-to-HDL-cholesterol (TG:HDL).Methods54,061 patients with BMI ≥ 18.5 kg/m2, mean age and duration 61.5 ± 8 and 6.9 ± 6 years, 59% males, 14% with CVD history, from the Swedish National Diabetes Register, followed for mean 4.8 years.ResultsAdjusting at Cox regression for non-BMI-linked (age, sex, smoking, CVD history) and BMI-linked (blood lipids, blood pressure, HbA1c, albuminuria) covariates, hazard ratios (HR) for fatal/nonfatal CHD and CVD were mainly increased with prominent obesity (BMI ≥ 35 kg/m2), 1.19 (p = 0.01) and 1.17 (p = 0.009), compared to normal weight (BMI 18.5–24.9 kg/m2), although increased also with obesity (BMI 30–34.9 kg/m2), 1.34 and 1.30 (p < 0.001), when adjusting only for non-BMI-linked covariates.Stratifying by 75th percentile of TG:HDL, with normal weight and TG:HDL < 1.9 as reference, obese and prominently obese with TG:HDL ≥ 1.9 had considerably increased HR around 1.7 for fatal/nonfatal CHD and 1.6 for CVD (p < 0.001), while obese and prominently obese with TG:HDL < 1.9 only had HR 1.2–1.3 for CHD and CVD (p 0.003–<0.01).ConclusionObese T2D patients with high TG:HDL, associated with increased insulin resistance, had considerably increased risk of CHD and CVD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 106, Issue 1, October 2014, Pages 136–144
نویسندگان
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