کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2796816 | 1155622 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management](/preview/png/2796816.png)
Nanothickness encapsulation using a layer-by-layer technique has applications in several areas of diabetes research, including improved glucose sensors, islet cell transplantation and oral insulin delivery. We have fabricated microvesicles containing a fluorescence lifetime-based glucose sensing system, with bacterial glucose-binding protein as the glucose receptor. Such sensors are suitable for impregnation in the dermis as a ‘smart tattoo’ type of non-invasive glucose monitoring technology. Nanoencapsulation of islet cells is intended to alleviate the immediate blood-mediated inflammatory reaction which is responsible for early islet loss post-transplant. In an allogeneic diabetic mouse model, nanoencapsulated islets with phosporylcholine-modified polysaccharide coating, significantly extended survival of transplanted islets. In early studies aimed at formulating an effective oral insulin preparation, insulin-chitosan colloids coated with nanolayers of chitosan and heparin had enhanced acid stability and effectively lowered blood glucose in an animal model.
Journal: Diabetes Research and Clinical Practice - Volume 100, Issue 2, May 2013, Pages 162–169