کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797258 1155639 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time-dependent impact of diabetes on the mortality of patients on renal replacement therapy: A population-based study in Germany (2002–2009)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Time-dependent impact of diabetes on the mortality of patients on renal replacement therapy: A population-based study in Germany (2002–2009)
چکیده انگلیسی

AimsTo estimate the impact of diabetes on the mortality of patients with incident renal replacement therapy (RRT).MethodsWe assessed the mortality of 544 incident RRT patients aged ≥30 years between 2002 and 2009 (57.9% men, mean age 70.3 years, 49.6% patients with diabetes) by analyzing the data of all dialysis centers covering a German region. We compared the estimated time-dependent hazard ratios of patients with and without diabetes by using the Cox proportional-hazards regression model.ResultsOverall, 319 patients had died (158 diabetic), approximately 50% after 3 years. Up to about 3 years, the mortality rate was lower in diabetic than in nondiabetic patients. Thereafter, the survival curves crossed (interaction diabetes × time, p = 0.002; adjusted hazard ratios for diabetes: baseline, 0.66; year 1, 0.84; year 2, 1.05; year 3, 1.33; year 4, 1.68). The results were similar in men and women; however, the interaction of diabetes and time was significant only in men (p = 0.004). Further significant risk factors of mortality were age, sex, initial central venous catheter, cardiovascular disease, and malignancy.ConclusionsIn this population-based study, the influence of diabetes was time-dependent, with a lower mortality in diabetic versus non-diabetic patients in the first three years but a higher mortality in these patients after 3 years. Results were similar in men and women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 92, Issue 3, June 2011, Pages 380–385
نویسندگان
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