کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2797551 | 1155657 | 2010 | 5 صفحه PDF | دانلود رایگان |
The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-γ as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-γ was detected by ELISA. Results of this study showed that the serum level of IFN-γ was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes.
Journal: Diabetes Research and Clinical Practice - Volume 87, Issue 1, January 2010, Pages 33–37