کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2797719 | 1155663 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 with PCOS and 120 without PCOS). None of the variants was associated with PCOS (PÂ <Â 0.05). However, the variant rs1052700*A was associated with increased risk for glucose intolerance (impaired glucose tolerance or T2DM) in both non-PCOS (ORÂ =Â 1.75 [1.02-3.01], PÂ =Â 0.044) and PCOS subjects (ORÂ =Â 1.67 [1.08-2.59], PÂ =Â 0.022). It was also associated with increased LDL (PÂ =Â 0.007) and total cholesterol levels (PÂ =Â 0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 86, Issue 3, December 2009, Pages 186-192
Journal: Diabetes Research and Clinical Practice - Volume 86, Issue 3, December 2009, Pages 186-192
نویسندگان
Toshihide Kawai, Maggie C.Y. Ng, M. Geoffrey Hayes, Issei Yoshiuchi, Takafumi Tsuchiya, Heather Robertson, Nancy J. Cox, Kenneth S. Polonsky, Graeme I. Bell, David A. Ehrmann,