کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797885 1155669 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NMR-determined lipoprotein subclass profile predicts type 2 diabetes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
NMR-determined lipoprotein subclass profile predicts type 2 diabetes
چکیده انگلیسی

AimsTo determine whether nuclear magnetic resonance (NMR)-determined lipoprotein profiles predict type 2 diabetes.MethodsSubjects were 813 male and female participants in the Melbourne Collaborative Cohort Study, aged 40–69 years at baseline (1990–1994), and with a baseline fasting plasma glucose <7.0 mmol/L. Incident type 2 diabetes was identified in 1994–1998 by self-report and confirmation from doctors. Eligible cases and a random group of controls were selected, with NMR data available for 59 cases and 754 non-cases.ResultsConcentration of very low density lipoprotein (VLDL) particles (positive) and high density lipoprotein (HDL) particle size (negative) were selected by stepwise regression as predictors of type 2 diabetes. These associations were independent of other non-lipid risk factors, but not plasma triglycerides. Factor analysis identified a factor from NMR variables, explaining 47% of their variation, and characterized by a positive correlation with VLDL, particularly large and medium sized; more low density lipoprotein (LDL) that were smaller; and relatively smaller, but not more HDL particles. This factor was positively associated with diabetes incidence, but not independently of triglycerides.ConclusionsWe identified an atherogenic NMR lipoprotein profile in people who developed diabetes, but this did not improve diabetes prediction beyond conventional triglyceride levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 83, Issue 1, January 2009, Pages 132–139
نویسندگان
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