کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797983 1155673 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diabetic nephropathy—What are the unmet needs?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Diabetic nephropathy—What are the unmet needs?
چکیده انگلیسی

In this pandemic of diabetes and obesity, Asia will have the highest number of affected people with the greatest increase in the young-to-middle aged group. Asian patients have increased risk for diabetic kidney disease which may be compounded by low grade infection, obesity and genetic factors. In these subjects, the onset of albuminuria and diabetic kidney disease causes further perturbation of metabolic milieu with increased oxidative stress, anaemia and vascular calcification which interact to markedly increase the risk of cardiovascular disease. Despite receiving optimal care to control blood pressure and metabolic risk factors as well as inhibition of the renin–angiotensin system in a clinical trial setting, there is a considerable residual risk for cardio-renal complications in patients with diabetic kidney disease. Control of obesity and low grade inflammation as well as correction of anaemia may represent areas where novel strategies can be developed and tested to curb this rising global burden of cardio-renal complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 82, Supplement 1, 13 November 2008, Pages S15–S20
نویسندگان
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