کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2798009 | 1155674 | 2008 | 6 صفحه PDF | دانلود رایگان |
BackgroundThe binding of advanced glycation end-products (AGEs) to their receptor for AGEs (RAGE) may play an important role in the development of diabetic vascular complications. Recently, soluble RAGE (sRAGE) has been identified as an alternative splicing form of RAGE. Furthermore, administration of sRAGE improved atherosclerosis in type 2 diabetic mice.ObjectiveThe objective of the present study is to investigate the role of endogenous secretory RAGE (esRAGE) as a biological marker for type 2 diabetic nephropathy, and also to determine whether serum esRAGE levels are associated with serum AGEs [including Nɛ–(carboxymethyl) lysine–protein adducts (CML) and pentosidine] levels.Materials and methodsSerum esRAGE levels were examined in 107 type 2 diabetic patients including those on hemodialysis (HD). Diabetic patients were divided into three groups as follows: Group A [patients without nephropathy, i.e. normoalbuminuric stage (AER < 30 μg/mg creatinine)], Group B [patients with nephropathy (AER > 30 μg/mg creatinine) but excluding HD patients], and Group C (HD patients).ResultsSerum esRAGE and AGEs (including CML and pentosidine) levels in Group C were significantly higher than in Group A or B. In single linear univariate correlation, serum esRAGE levels were correlated using body mass index (BMI), duration of diabetes, and serum creatinine, high-density lipoprotein (HDL)-cholesterol and AGEs (including CML and pentosidine) levels. Furthermore, in stepwise multivariate regression analysis, the levels of serum creatinine and duration of diabetes were independently associated with serum esRAGE levels.ConclusionSerum esRAGE levels are associated with the severity of renal dysfunction and duration of diabetes in type 2 diabetic patients.
Journal: Diabetes Research and Clinical Practice - Volume 81, Issue 2, August 2008, Pages 196–201