Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects

AimsWe investigated the relationship of urinary albumin excretion (UAE) to metabolic syndrome and type 2 diabetes in Asian.MethodsA total of 446 subjects (187 without diabetes and 259 with type 2 diabetes) were enrolled in this study. The components of metabolic syndrome, high sensitivity C-reactive protein (hs-CRP) and UAE were assessed. Based on metabolic syndrome and diabetes status, participants were categorized into one of the following groups: neither metabolic syndrome nor diabetes (MS−DM−), metabolic syndrome without diabetes (MS+DM−), diabetes without metabolic syndrome (MS−DM+) and both metabolic syndrome and diabetes (MS+DM+).ResultsThe UAE in the MS+DM− group was higher than that in the MS−DM− group (P < 0.001) and lower than that in the MS+DM+ group (P < 0.001), but not significantly different from that in the MS−DM+ group (P = 0.349). The trend of increasing UAE in these four groups was independent of hs-CRP.ConclusionUAE was lowest in subjects with neither metabolic syndrome nor diabetes and highest in subjects with both metabolic syndrome and type 2 diabetes; however, there was no significant difference between the metabolic syndrome alone group and the type 2 diabetes alone group.