کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2798245 1568808 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus
چکیده انگلیسی

AimsTo compare the postprandial lipid responses in subjects with prediabetes (IFG and IGT), newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT).MethodsPostprandial lipid responses to a standard oral fat challenge was studied in forty-four subjects who were divided after an OGTT into NGT, pure impaired fasting glucose (PIFG), pure impaired glucose tolerance (PIGT) and NDDM.ResultsThere was a significantly higher postprandial triglyceride (PPTg) response with a higher PPTg area under curve (p = 0.004) and peak PPTg levels (p = 0.003) in patients with NDDM but not with either PIFG (p > 0.05) or PIGT (p > 0.05) when compared with NGT. Overall, PPTg responses correlated significantly with fasting plasma glucose (p = 0.001) and 2 h plasma glucose (p = 0.001) but not with age, sex, body mass index, waist, or insulin resistance.ConclusionSubjects with newly detected diabetes mellitus displayed postprandial hypertriglyceridemia after a standard oral fat meal challenge while no such abnormality could be demonstrated in subjects with IFG or IGT. This defect is probably related to glycemic status and insulin resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 80, Issue 3, June 2008, Pages 380–385
نویسندگان
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