کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2798745 | 1155698 | 2007 | 7 صفحه PDF | دانلود رایگان |
ObjectiveType 2 diabetes (T2DM) is characterized by increased proinsulin-to-insulin ratio (P/I ratio), increased glycation and oxidative stress, and β-cell dysfunction. Previous reports implicated that increased P/I ratio, glycation and oxidative stress constitute markers of β-cell dysfunction in T2DM. However, its clinical relevance remains to be elucidated. Therefore, in the present study we investigated the relationship between the P/I ratio, glycation and oxidative stress markers in patients with T2DM, using newly developed intact chemiluminescent immunoassay for proinsulin.MethodsFasting intact proinsulin, insulin, advanced glycation endproducts (AGEs), pentosidine, lipid peroxide and urine 8-isoprostane as well as other metabolic parameters were measured in 64 T2DM subjects.ResultsUsing univariate analysis, P/I ratio showed significant positive correlations with plasma glucose (r = 0.465), HbA1c (r = 0.434) and AGEs (r = 0.282), and significant negative correlations with insulin (r = −0.330) and HOMA-β (r = −0.520) even after adjustment for age, sex, duration of diabetes, family history of diabetes, use of sulfonylureas, smoking and body mass index. Additionally, stepwise multiple regression analysis revealed that HOMA-β, HbA1c and AGEs were independently and significantly correlated with P/I ratio.ConclusionThese findings suggest that not only hyperglycemia per se but also glycation is involved in β-cell dysfunction in T2DM subjects.
Journal: Diabetes Research and Clinical Practice - Volume 78, Issue 2, November 2007, Pages 182–188