کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2798776 1155699 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strength–duration properties in diabetic polyneuropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Strength–duration properties in diabetic polyneuropathy
چکیده انگلیسی

We sought to examine the changes in the strength–duration time constant (SDTC) of the median nerve in diabetic polyneuropathy. The SDTC is a measure of axonal excitability and depends on the biophysical properties of the axonal membrane. It may provide some information about Na+ channel functioning. Forty-nine diabetic patients (30 men, 19 women; mean age, 54.6 ± 9.4 years) and 15 age-matched healthy subjects (11 men, 4 women; mean age, 53.1 ± 7.6 years) participated in the study. SDTC and rheobase values were 384.5 ± 97.9 μs and 4.6 ± 2.4 mA in patients and 313.8 ± 46.7 μs and 6.0 ± 2.6 mA in controls. The SDTC was found to be significantly different between the two groups (P = .009 for SDTC and P = .066 for rheobase). Fasting glucose and HbA1c levels of patients were 206.6 ± 88.7 mg/dL and 8.8 ± 2.4%, and these were not correlated with SDTC or rheobase (P < .05). We suggest that longer SDTC, indicating increased axonal excitability may develop in patients with polyneuropathy associated with uncontrolled diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 78, Issue 1, October 2007, Pages 56–59
نویسندگان
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