کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2799010 | 1155711 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The spontaneously diabetic Torii rat with gastroenteropathy
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
The spontaneously diabetic Torii (SDT) rat was recently recognized as a new animal model of non-obese type 2 diabetes. As the severe diabetic ocular complications seen in SDT rats already have been investigated, we examined another common diabetic complication, gastroenteropathy. Male SDT rats developed diabetes at 20 weeks and diarrhea at 28 weeks of age. Gastrointestinal motility was evaluated at 28 weeks by measuring the distance of small intestinal transit by oral administration of the non-absorbed marker, arabic gum. SDT rats exhibited greater intestinal transit distance than control SD rats (54.1 ± 2.6% versus 43.0 ± 1.2%). Insulin treatment of SDT rats begun at 20 weeks of age produced improved stool and reduced intestinal transit distance (41.4 ± 0.3%). Morphologically, the SDT rats exhibited longer villi and heavier weight of intestine compared to control SD rats. These results suggest that the SDT rat may be a useful animal model for studies of diabetic gastroenteropathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 75, Issue 2, February 2007, Pages 127-134
Journal: Diabetes Research and Clinical Practice - Volume 75, Issue 2, February 2007, Pages 127-134
نویسندگان
Kotaro Yamada, Masaya Hosokawa, Shimpei Fujimoto, Kazuaki Nagashima, Kazuhito Fukuda, Hideya Fujiwara, Eiichi Ogawa, Yoshihito Fujita, Naoya Ueda, Futoshi Matsuyama, Yuichiro Yamada, Yutaka Seino, Nobuya Inagaki,