Changes in plasma angiotensin subtypes in Japanese eel acclimated to various salinities from deionized water to double-strength seawater

► Development of a high resolution method to quantify various angiotensin subtypes. ► Plasma Ang II is significantly increased in double-strength seawater. ► Plasma osmolality is the major stimulus for Ang II during seawater transfer. ► Conversion of [Asn1, Val5]-Ang II to [Asp1, Val5]-Ang II does not occur in plasma. ► Asparaginase activity is the highest in liver in FW and SW eel.