کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2805490 1157056 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics
ترجمه فارسی عنوان
یک نوع ژن کوائولین-1 شایع با سندرم متابولیک در قفقاز و اسپانیایی تبار است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

Context and objectiveWe examined whether a prevalent caveolin-1 gene (CAV1) variant, previously related to insulin resistance, is associated with metabolic syndrome (MetS).Patients and methodsWe included subjects genotyped for the CAV1 variant rs926198 from two cohorts: 735 Caucasians from the HyperPATH multicenter study, and 810 Hispanic participants from the HTN–IR cohort.ResultsMinor allele carriers from HyperPATH cohort (57% of subjects) had higher Framingham risk scores, higher odds of diabetes (10.7% vs 5.7%, p = 0.016), insulin resistance (44.3% vs 35.1%, p = 0.022), low HDL (49.3% vs 39.6%, p = 0.018) and MetS (33% vs 20.5%, p < 0.001) but similar BMI. Consistently, minor allele carriers exhibited higher odds of MetS, even when adjusted for confounders and relatedness (OR 2.83 (1.73–4.63), p < 0.001). The association with MetS was replicated in the Hispanic cohort HTN–IR (OR 1.61, [1.06–2.44], p = 0.025). Exploratory analyses suggest that MetS risk is modified by a CAV1 variant–BMI status interaction, whereby the minor allele carrier status strongly predicted MetS (OR 3.86 [2.05–7.27], p < 0.001) and diabetes (OR 2.27 [1.07–4.78], p = 0.03) in non-obese, but not in obese subjects. In addition, we observed a familial aggregation for MetS diagnosis in minor allele carriers.ConclusionThe prevalent CAV1 gene variant rs926198 is associated with MetS in separate Caucasian and Hispanic cohorts. These findings appear to be driven by an interaction between the genetic marker and obesity status, suggesting that the CAV1 variant may improve risk profiling in non-obese subjects. Additional studies are needed to confirm the clinical implications of our results.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 64, Issue 12, December 2015, Pages 1674–1681
نویسندگان
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