کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2805623 1157067 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans
چکیده انگلیسی

BackgroundGlucose-stimulated insulin secretion correlates inversely with the degree of whole-body insulin sensitivity suggesting a crosstalk between peripheral organs and pancreas. Such sensing mechanism could be mediated by changes in glucose flux (uptake, oxidation or storage) in peripheral tissues that may drive insulin secretion.AimTo relate whole-body non-protein respiratory quotient (npRQ), an index of macronutrient oxidative partitioning, with insulin secretion and β-cell function in non-diabetic individuals.MethodsMacronutrient oxidation was measured after an overnight fast and for 4 h after a 75-g oral glucose tolerance test (OGTT) in 30 participants (15/15 males/females; 35 ± 12 y; 27 ± 4 kg/m2). Furthermore, npRQ was assessed for 24 h in a metabolic chamber. Insulin secretion was estimated by deconvolution of serum C-peptide concentration (fasting and 4-h OGTT) and from 24-h urinary C-peptide excretion corrected for energy intake (metabolic chamber). β-Cell function parameters were obtained by mathematical modeling, while insulin sensitivity was determined by a euglycemic–hyperinsulinemic clamp (120 mU · m− 2 · min− 1).ResultsInsulin secretion (from 24-h urinary C-peptide) correlated inversely with 24-h npRQ (r = − 0.61; p = 0.001), even after controlling for insulin sensitivity, energy balance, age and body mass index (r = − 0.52; p = 0.01). In turn, insulin secretion (from serum C-peptide) was not associated with fasting or OGTT npRQ. However, fasting npRQ was positively correlated with rate sensitivity (r = 0.40; p < 0.05) and marginally with glucose sensitivity (r = 0.34; p = 0.08).ConclusionMacronutrient oxidative partitioning, specifically glucose oxidation, might play a role on the regulation of insulin secretion. Further studies should aim at identifying the signals linking these processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 63, Issue 11, November 2014, Pages 1426–1431
نویسندگان
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