کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2805691 1157072 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise
چکیده انگلیسی

ObjectiveTo investigate the efficacy and underlying mechanisms of β-hydroxy-β-methylbutyrate (HMB) on body composition, muscle mass and physical performance under catabolic versus normal training conditions.Materials/MethodsMice were divided into four groups (n = 10/group): 1) ALT = ad libitum + trained (1 h/d for 3 d/wk); 2) ALTH = ALT + HMB (0.5 g/kg BW/d); 3) C = calorie restricted (− 30%) + trained (6 h/d, 6 d/wk); and 4) CH = C + HMB. Repeated in vivo assessments included body composition, grip strength and sensorimotor coordination before and after the experimental protocol, while in vitro analyses included muscle wet weights, expression of selected genes and proteins regulating muscle mass, and myofiber cross-sectional area. ANOVAs were used with significance set at p < 0.05.ResultsALTH had greater lean mass than ALT and sensorimotor function increased in ALTH, but decreased in ALT under normal training conditions. Grip strength decreased only in C, but was maintained in CH. Gastrocnemius mass and myofiber CSA were greater in CH than C following catabolic conditions. Gastrocnemius atrogin-1 mRNA expression was elevated in C but not in CH compared to all other groups whereas atrogin-1 protein levels showed no significant changes.ConclusionHMB improves body composition and sensorimotor function during normal training and attenuates muscle mass and strength loss during catabolic conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 62, Issue 12, December 2013, Pages 1718–1729
نویسندگان
, , , , , , ,