کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2807869 1157200 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Key role of insulin resistance in vascular injury among hemodialysis patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Key role of insulin resistance in vascular injury among hemodialysis patients
چکیده انگلیسی
Insulin resistance prevails not only among diabetic patients but also among hypertensive and obese patients. The relationship between insulin resistance and cardiovascular diseases was investigated in hemodialysis (HD) patients. Eighty-one maintenance HD patients were enrolled. The homeostasis model assessment of insulin resistance (HOMA-IR) method was used to assess insulin resistance. The relationship of HOMA-IR with cardiovascular and all-cause events was assessed. Compared with nondiabetic patients (n = 55), diabetic patients (n = 26) showed higher HOMA-IR (2.5 ± 0.3 vs 1.4 ± 0.2, P < .05), lower ankle-brachial pressure index (ABI, 0.85 ± 0.09 vs 1.12 ± 0.02, P < .01), and shorter HD duration (3 ± 1 vs 9 ± 1 years, P < .01), although their body mass index was similar (22.3 ± 0.5 vs 21.5 ± 0.4 kg/m2). Nondiabetic patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (n = 36) had lower HOMA-IR (1.2 ± 0.2 vs 1.8 ± 0.4, P < .05) and higher ABI (1.18 ± 0.02 vs 1.02 ± 0.05, P < .01) than those without (n = 17). Cardiovascular events were less common in HD patients with normal HOMA-IR (P < .05) or ABI (P < .01). Our data indicate that 69% of diabetic and 27% of nondiabetic patients have HOMA-IR greater than 1.6, implying reduced insulin sensitivity in HD patients. The present results provide evidence that angiotensin inhibition improves insulin resistance, possibly preventing vascular injury in HD patients. Finally, our findings suggest that insulin resistance is prognostic of cardiovascular events in HD patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 56, Issue 2, February 2007, Pages 153-159
نویسندگان
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