کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2809322 1158034 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alterations in lipid profile of autistic boys: a case control study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Alterations in lipid profile of autistic boys: a case control study
چکیده انگلیسی

We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys. A matched case control study was conducted with 29 autistic boys (mean age, 10.1 ± 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured. Multiple regression analyses were performed to assess the association between autism and various lipid fractions. The mean TG level (102.4 ± 52.4 vs 70.6 ± 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 ± 11.9 vs 60.5 ± 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls. There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls. Multiple regression analyses indicated that autism was significantly associated with plasma TG (β = 31.7 ± 11.9; P = .01), HDL (β = −11.6 ± 2.1; P = .0003), and the LDL/HDL ratio (β = 0.40 ± 0.18; P = .04). There was a significant interaction between autism and TG level in relation to plasma HDL level (P = .02). Fifty-three percent of variation in the plasma HDL was explained by autism, plasma TG, LDL/HDL ratio, and the interaction between autism and plasma TG level. These results indicate the presence of dyslipidemia in boys with autism and suggest a possibility that dyslipidemia might be a marker of association between lipid metabolism and autism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 30, Issue 4, April 2010, Pages 255–260
نویسندگان
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