کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2810027 | 1158136 | 2006 | 6 صفحه PDF | دانلود رایگان |

The objective of this study was to determine if obstructive sleep apnea (OSA) subjects had elevated plasma homocysteine levels and a greater incidence of traditional cardiovascular risk factors. Case subjects (OSA group, n = 24) without cardiovascular disease had an apnea-hypopnea index of 5 or higher; control subjects without cardiovascular disease served as a non-OSA group (n = 65). Demographic and anthropometric (ie, weight, height, body mass index [BMI], neck, waist, and hip circumferences) data were collected. Systolic and diastolic blood pressure (DBP) were measured. Fasting venous blood samples were collected to determine total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, creatinine, homocysteine, vitamin B6, vitamin B12, and folate status. In univariate analysis, BMI; neck, waist, and hip circumferences; serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and DBP were all positively associated with OSA. Plasma homocysteine concentration, however, had no effect on OSA. The age-adjusted odds ratio (OR) for all OSA and control subjects was significantly increased in the third tertile of homocysteine concentration (OR, 9.29; 95% CI, 1.25-69.12). However, the third tertile of plasma homocysteine showed no effect (OR, 3.24; 95% CI, 0.02-497.80) on OSA after additional adjustment for all cardiovascular risk factors. Homocysteine had no association with OSA; however, obesity, DBP, and serum total cholesterol are associated with OSA. Indices of central obesity (BMI and waist and neck circumferences) and a combination with DBP and serum total cholesterol level should be screened in patients with OSA.
Journal: Nutrition Research - Volume 26, Issue 2, February 2006, Pages 59–64