کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810569 1158458 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat
چکیده انگلیسی

The hypothalamus regulates the skeleton and adipose tissue via endocrine mechanisms. Changes in sex steroid levels in menopause and aging are central to the associated changes in bone mass and adiposity. Whereas many of these effects occur via direct actions on osteoblasts or adipocytes, sex hormones can also mediate effects on bone and adipose tissue via interaction with neuronal pathways. A key hypothalamic regulator of bone and adipose tissue is neuropeptide Y (NPY), which coordinately influences these tissues via effects on neuroendocrine and sympathetic nervous output. Better understanding of the interaction between NPY and sex steroids in regulating skeletal and energy homeostasis could lead to more effective treatments for osteoporosis and obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 7, July 2010, Pages 411–418
نویسندگان
, , , , ,