کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810616 1158463 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging roles of JAK–STAT signaling pathways in adipocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Emerging roles of JAK–STAT signaling pathways in adipocytes
چکیده انگلیسی

Twenty years ago, adipocytes were largely considered to be inert energy-storage depots. We now know that fat cells are highly insulin-sensitive with significant endocrine functions. Alterations in adipocyte development or function can contribute to metabolic disease, in particular type 2 diabetes. The current obesity epidemic that plagues many nations provides a strong rationale for understanding basic adipocyte biology. The JAK–STAT signaling pathway mediates the action of a variety of hormones that have profound effects on adipocyte development and function. In addition, adipocytes secrete hormones that utilize this signaling pathway. This review summarizes research on the expression and function of JAKs and STATs in adipocytes and highlights the roles of JAK–STAT-activating cytokines in adipose tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 22, Issue 8, August 2011, Pages 325–332
نویسندگان
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