کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810729 1158475 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leptin receptor modulation of adiposity and fertility
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Leptin receptor modulation of adiposity and fertility
چکیده انگلیسی

The leptin receptor was discovered as a leptin binding protein, which is highly expressed in the choroid plexus. Mapping of the gene's chromosomal locations in rodents revealed that mutations in Lepr were the basis of obesity/diabetes mutations in rodents and humans. Genetic manipulations that target Lepr expression in specific neurons or hypothalamic areas have generated insights into the modes by which body composition and reproductive function are modulated by the leptin receptor. These animal models have also been instrumental in identifying diabetes susceptibility genes. In this review we discuss the evidence that supports the concept of networked functions of leptin receptor as it pertains to feeding, substrate utilization and reproduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 1, January 2010, Pages 10–16
نویسندگان
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