کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810730 1158475 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lysophosphatidic acid (LPA) signaling in vertebrate reproduction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Lysophosphatidic acid (LPA) signaling in vertebrate reproduction
چکیده انگلیسی

Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA1–5, and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects of vertebrate reproduction. These include ovarian function, spermatogenesis, fertilization, early embryo development, embryo implantation, embryo spacing, decidualization, pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and ovarian cancer. Here we review recent progress in LPA signaling research relevant to female and male reproduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 1, January 2010, Pages 17–24
نویسندگان
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