کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810808 1158482 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The human fetal adrenal cortex and the window of sexual differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The human fetal adrenal cortex and the window of sexual differentiation
چکیده انگلیسی

Understanding normal development is fundamental to appreciating postnatal morphology, physiology and, in some instances, pathophysiology. Developmental biology tends to interrogate models in nonprimate species, for instance the mouse, where genetic manipulation gives privileged insight into the function of particular genes. Some human developmental processes, as occur in the adrenal gland, are not faithfully reproduced in these rodent models, yet have an impact on the pathophysiology and treatment of endocrine disorders, such as congenital adrenal hyperplasia. In this setting, in vitro research of normal human development complements clinical investigation of patients born with congenital disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 10, December 2006, Pages 391–397
نویسندگان
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