کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810867 1158488 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action
چکیده انگلیسی

The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic and cell-survival activities. IGF-IR levels are tightly regulated by the concerted action of secreted (e.g. peptide and steroid hormones, growth factors and cytokines) and cellular (e.g. transcription factors, oncogenes and tumor suppressors) factors. The mode of action of many tumor suppressors involves transcriptional suppression of the IGF-IR gene, with a subsequent reduction in cell-surface IGF-IR concentrations and IGF-I action. Loss-of-function mutation of tumor suppressors, a common theme in human cancer, can lead to aberrant regulation of IGF-IR gene expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 6, August 2006, Pages 236–242
نویسندگان
, ,