کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810965 1158500 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The intracellular renin–angiotensin system: a new paradigm
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The intracellular renin–angiotensin system: a new paradigm
چکیده انگلیسی

More than a century after its discovery, the physiological implications of the renin–angiotensin system (RAS) continue to expand, with the identification of new components, functions and subsystems. These advancements have led to better management and understanding of a broad range of cardiovascular and metabolic disorders. The RAS has traditionally been viewed as a circulatory system, involved in the short-term regulation of volume and blood pressure homeostasis. Recently, local RASs have been described as regulators of chronic tissue effects. Most recently, studies have provided evidence of a complete, functional RAS within cells, described as an ‘intracrine’ or intracellular system. A more comprehensive understanding of the intracellular RAS provides for new strategies in system regulation and a more efficacious approach to the management of RAS-related diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 5, July 2007, Pages 208–214
نویسندگان
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