کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811000 1158506 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Menin and its interacting proteins: elucidation of menin function
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Menin and its interacting proteins: elucidation of menin function
چکیده انگلیسی

The multiple endocrine neoplasia type 1 (MEN1) gene is a tumor suppressor gene encoding a 610 amino acid nuclear protein, menin. Although mutations of the MEN1 gene are responsible for MEN 1 syndrome, the intracellular functions of menin have not been fully elucidated. Recent data suggest that interactions between menin and menin-interacting proteins have a role in physiological regulation of cell growth, control of the cell cycle and genome stability, and are potentially important in bone development and multipotent mesenchymal stem cell differentiation. Loss of these interactions might also contribute to the development of MEN 1 syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 9, November 2006, Pages 357–364
نویسندگان
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