کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811002 1158506 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of leptin antagonists and their potential use in experimental biology and medicine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Development of leptin antagonists and their potential use in experimental biology and medicine
چکیده انگلیسی

Leptin is a pleotropic hormone that acts both centrally and peripherally. Whereas leptin exhibits positive effects on several physiological functions, such as regulation of energy metabolism, reproductive function and immune responses, negative actions, such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure and cardiovascular pathologies, have also been documented. The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 9, November 2006, Pages 372–378
نویسندگان
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