کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811017 1158508 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adipose stress-sensing kinases: linking obesity to malfunction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Adipose stress-sensing kinases: linking obesity to malfunction
چکیده انگلیسی

Obesity has been proposed to inflict a variety of stresses on adipose tissue, including inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation of ‘stress-sensing pathways’, metabolic and endocrine alterations are produced, which probably contribute to the co-morbidities associated with obesity. Here, we review the evidence supporting the development of various obesity-related stresses and the activation of several stress-sensing pathways, specifically in adipocytes and/or adipose tissue, which manifest metabolic and endocrine dysfunction frequently in obesity. As the central role of adipose tissue in regulating whole-body metabolism is elucidated, understanding adipose tissue stress-sensing pathways might provide potential new therapeutic targets to attenuate obesity-related morbidity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 8, October 2007, Pages 291–299
نویسندگان
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