کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811030 1158509 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances
چکیده انگلیسی

Cushing's syndrome (CS), which is caused by excessive circulating glucocorticoid concentrations, is rare in the paediatric age range but presents a diagnostic and therapeutic challenge. Most paediatric endocrinologists have limited experience of managing children or adolescents with CS and thus benefit from close consultation with colleagues who treat adult patients. A protocol for investigation is required that broadly follows the model for adult patients. Here, the epidemiology and diagnosis of different causes of CS are discussed according to typical age of presentation. Treatment strategies for adrenocorticotrophic hormone (ACTH)-independent and ACTH-dependent CS are described and critically appraised. The management of paediatric CS patients after cure also presents challenges for optimizing growth, bone health, reproduction and body composition from childhood into and during adult life.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 4, May–June 2007, Pages 167–174
نویسندگان
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