کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811074 1158516 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
چکیده انگلیسی

In type 2-diabetes and impaired glucose tolerance, the muscle, fat and liver become resistant to insulin, and recent developments place dysregulation of insulin receptor substrate (IRS) expression and activation at the center of such defects. IRS1 and IRS2 are the major insulin receptor substrates leading to glucose homeostasis, and have distinct and overlapping roles in diverse organs. The majority of the published literature in this field suggests that IRS1 is the major substrate leading to stimulation of glucose transport in muscle and adipose tissues, whereas in liver, IRS1 and IRS2 have complementary roles in insulin signaling and metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 2, March 2006, Pages 72–78
نویسندگان
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