کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811081 1158517 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular mechanisms of estradiol-mediated sexual differentiation of the brain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cellular mechanisms of estradiol-mediated sexual differentiation of the brain
چکیده انگلیسی

Gonadal steroids organize the developing brain during a perinatal sensitive period and have enduring consequences for adult behavior. In male rodents testicular androgens are aromatized in neurons to estrogens and initiate multiple distinct cellular processes that ultimately determine the masculine phenotype. Within specific brain regions, overall cell number and dendritic morphology are the principal targets for hormonal organization. Recent advances have been made in elucidating the cellular mechanisms by which the neurological underpinnings of sexually dimorphic physiology and behavior are determined. These include estradiol-mediated prostaglandin synthesis, presynaptic release of glutamate, postsynaptic changes in glutamate receptors and changes in cell adhesion molecules. Sex differences in cell death are mediated by hormonal modulation of survival and death factors such as TNFα and Bcl-2/BAX.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 9, September 2010, Pages 553–561
نویسندگان
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