کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811154 1158554 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy
چکیده انگلیسی

Nuclear receptors represent novel targets for the development of therapeutic agents for the treatment of numerous diseases, including type 2 diabetes, obesity dyslipidemia, atherosclerosis and the metabolic syndrome. There have been many recent advances in the development of new therapeutic agents for a subset of these receptors, including the peroxisome proliferator-activated receptors, the liver X receptors and the farnesoid X receptor. To date, the synthesis of selective modulators that regulate the activity of these receptors has been empirical. However, a detailed understanding of the molecular basis for selective modulation, as well as new insights into the biology of these receptors, might open the door to the rational design of a new generation of therapeutic agents with improved safety and efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 7, September 2006, Pages 284–290
نویسندگان
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