کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2811168 1158558 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studying non-mammalian models? Not a fool's ERRand!
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Studying non-mammalian models? Not a fool's ERRand!
چکیده انگلیسی

Through studies in mammalian model systems, the estrogen-receptor-related receptor (ERR) α, an orphan nuclear receptor, has been shown to interfere with estrogen signaling and might therefore be an interesting pharmaceutical target in estrogen-related diseases. ERRα is also involved in energy storage and consumption, and its modulation might be of relevance in the treatment of obesity and diabetes. Recent data have also been published on the effects of this receptor, as well as other members of the ERR family, in non-mammalian animal model systems. Besides indications concerning their mechanisms of action, this analysis demonstrated a role for ERRα in controlling cellular movements, and suggested that ERRs might be implicated in a more subtle range of processes than originally envisioned.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 4, May 2006, Pages 166–171
نویسندگان
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