کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2822059 | 1570120 | 2015 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The conserved HDAC Rpd3 drives transcriptional quiescence in S. cerevisiae The conserved HDAC Rpd3 drives transcriptional quiescence in S. cerevisiae](/preview/png/2822059.png)
Quiescence is a ubiquitous cell cycle stage conserved from microbes through humans and is essential to normal cellular function and response to changing environmental conditions. We recently reported a massive repressive event associated with quiescence in Saccharomyces cerevisiae, where Rpd3 establishes repressive chromatin structure that drives transcriptional shutoff [6]. Here, we describe in detail the experimental procedures, data collection, and data analysis related to our characterization of transcriptional quiescence in budding yeast (GEO: GSE67151). Our results provide a bona fide molecular event driven by widespread changes in chromatin structure through action of Rpd3 that distinguishes quiescence as a unique cell cycle stage in S. cerevisiae.
Journal: Genomics Data - Volume 6, December 2015, Pages 245–248