کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2822918 | 1570162 | 2016 | 8 صفحه PDF | دانلود رایگان |
• The search for homologous recombination events in canine distemper virus was performed.
• Eight new potential recombinant strains were found and characterized.
• Evidence of recombination between field and vaccine strains was found.
• It was hypothesized that recombination with vaccine strains could have an effect on CDV evolution.
Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many members of Paramyxoviridae, these events have rarely been reported for CDV. To detect potential recombination events, the complete CDV genomes available in GenBank up to June 2015 were screened using distinct algorithms to detect genetic conversions and incongruent phylogenies. Eight putative recombinant viruses derived from different CDV genotypes and different hosts were detected. The breakpoints of the recombinant strains were primarily located on fusion and hemagglutinin glycoproteins. These results suggest that homologous recombination is a frequent phenomenon in morbillivirus populations under natural replication, and CDV vaccine strains might play an important role in shaping the evolution of this virus.
Journal: Infection, Genetics and Evolution - Volume 41, July 2016, Pages 262–269