کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823007 1570172 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genome characterization of a GII.6 norovirus strain identified in China
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Genome characterization of a GII.6 norovirus strain identified in China
چکیده انگلیسی


• The genome of a GII.6 NoV strain in China was obtained and characterized.
• Five codon sites on GII.6 NoV capsid were found under positive selection.
• Fifty-three spots on the GII.6 NoV capsid showed subcluster specificity.
• The predicted antigen distribution on GII.6 capsid was different from that of GII.4.

Noroviruses (NoVs) are the primary cause of non-bacterial acute gastroenteritis worldwide. Most NoV infections are caused by GII.4, but GII.6 is also an important genotype with a long-term persistence in human populations. In this study, the complete genome sequence of a NoV strain GZ2010-L96 isolated in China was identified and analyzed phylogenetically. The viral genome comprised 7550 nucleotides, and its phylogenetic analysis revealed that the strain belonged to GII.6 genotype. All reported GII.6 NoV capsid protein sequences were also collected for comparative analysis, and GZ2010-L96 was clustered into GII.6-b with other 8 strains. Meanwhile, it was found that 53 spots on viral capsid showed subcluster specificity according to multiple alignments. Moreover, homologous modeling of GZ2010-L96 based on comparison with GII.4 VA387 strain showed a different antigen distribution pattern. In summary, the genome of the GII.6 strain GZ2010-L96 detected in China was extensively characterized, and phylogenetic analyses of GII.6 NoVs based on the capsid proteins may reveal a different evolution process from the predominant genotype GII.4.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 31, April 2015, Pages 110–117
نویسندگان
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