کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823634 1161396 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary dynamics and spatial genetic structure of epizootic hemorrhagic disease virus in the eastern United States
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Evolutionary dynamics and spatial genetic structure of epizootic hemorrhagic disease virus in the eastern United States
چکیده انگلیسی

Epizootic hemorrhagic disease virus (EHDV) is a significant pathogen of wild and domestic ungulates worldwide. In North America, serotype EHDV-2 is responsible for the majority of outbreaks, which are most commonly observed in white-tailed deer. A recent study by Murphy et al. [Murphy, M.D., Howerth, E.W., MacLachlan, N.J., Stallknecht, D.E., 2005. Genetic variation among epizootic hemorrhagic disease viruses in the southeastern United States: 1978–2001. Infect. Genet. Evol. 5, 157–165] examined the genetic relationships of EHDV-2 sequences from outbreaks across the eastern United States for evidence of temporal and spatial structure but found no evidence for either. Here, I present results of further examination of the same data using additional types of analysis. Contrary to the earlier assessment, I find that for outbreaks observed within the same year, genetic and spatial distances are in fact positively correlated and that the virus is evolving at a rate similar to that seen in other vector-born RNA viruses. Estimates of demographic history further revealed that population sizes of the virus had remained relatively stable over most of its history. A noticeable exception to this trend was a recent demographic bottleneck, possibly associated with a selective sweep, that affected one of the two viral genes examined. These results demonstrate that genetic variation accumulating at selectively neutral and measurably evolving sites in the EHDV-2 genome can be employed to gain insights into the spatial and temporal dynamics of this viral pathogen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 7, Issue 5, September 2007, Pages 651–655
نویسندگان
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